Can Factors Predict Psychiatric Effects with Smoking Cessation Drugs?

Some people who use medications to quit smoking experience psychiatric side effects. Now researchers say they have identified characteristics in individuals that can help predict whether they will experience these effects while taking a smoking cessation drug.

Researchers conducted a secondary analysis of a 2016 study known as EAGLES, which examined psychiatric side effects associated with smoking cessation drugs and nicotine patches. The two most commonly prescribed such medications are Chantix (varenicline) and Zyban (bupropion). The EAGLES study was funded by Pfizer and GlaxoSmithKline, the respective manufacturers of the two drugs. Earlier results found that about 6% of those with a prior history of mental illness had a moderate-to-severe psychiatric event while taking a smoking cessation medication, compared to 2% with no prior history.

The new analysis found that having anxiety, a history of suicidal ideation or behavior and being white were associated with a higher risk of significant psychiatric events – irrespective of current mental health status – while taking a smoking cessation aid, the researchers reported in the Journal of General Internal Medicine.

In those with a history of mental illness, predictors of psychiatric side effects while using smoking cessation drugs were being young, female, a long-term smoker and having a history of psychiatric and substance abuse disorders occurring at the same time.


Did you find this article helpful?


Latest News

Breaking News – EpiPen Malfunction

Breaking News – EpiPen Malfunction

Just released from the FDA – Pfizer has informed the FDA that they are aware of several continuing problems that people are having using the EpiPen (epinephrine) and EpiPen Jr (epinephrine) auto-injectors and generic versions. Some of the problems are from user error and some from EpiPen malfunction. Here are…

ACE Inhibitors in the Time of Coronavirus

ACE Inhibitors in the Time of Coronavirus

Are you worried about ACE inhibitors and coronavirus? You may be hearing that one of the entry methods for the coronavirus in humans is by attaching to the ACE-2 enzyme. This has raised alarms among those with heart disease who use ACE inhibitors (with names ending in -pril, such as…

  • Advertisement